Tunicamycin 16:1 Mixture

Tunicamycin 16:1 is a mixture of tunicamycin structural isomers that contain a 16-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 16:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) in Streptomyces and directly impacts the biological activity of each individual tunicamycin variant. Purified tunicamycin 16:1 with the iso branching configuration inhibits bacterial phospho-MurNAc-pentapeptide transferase (MraY) with an IC50 value of 0.11 µM.Molecular Formula: C39H64N4O16. Formula Weight: 844.9. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 260 nm. SMILES: CC(N[C@H]1[C@@H](O[C@@]2([H])[C@H](NC(/C=C/CCCCCCCCCCC(C)C)=O)[C@@H](O)[C@@H](O)[C@@H](C[C@@H](O)[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=CC(NC4=O)=O)O3)O2)O[C@H](CO)[C@@H](O)[C@@H]1O)=O. InChi Code: InChI=1S/C39H64N4O16/c1-20(2)14-12-10-8-6-4-5-7-9-11-13-15-25(47)41-28-32(52)29(49)23(56-38(28)59-37-27(40-21(3)45)31(51)30(50)24(19-44)57-37)18-22(46)35-33(53)34(54)36(58-35)43-17-16-26(48)42-39(43)55/h13,15-17,20,22-24,27-38,44,46,49-54H,4-12,14,18-19H2,1-3H3,(H,40,45)(H,41,47)(H,42,48,55)/b15-13+/t22-,23-,24-,27-,28-,29+,30-,31-,32-,33+,34-,35-,36-,37-,38+/m1/s1. InChi Key: ZOCXUHJGZXXIGQ-NPXWYGMKSA-N.