Tropolone

Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities. It inhibits catechol O-methyltransferase (COMT, Ki = 22 µM). Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM. It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM). Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats. Dietary administration of tropolone induces growth retardation and hyperactivity in mice.Formal Name: 2-hydroxy-2,4,6-cycloheptatrien-1-one. CAS Number: 533-75-5. Synonyms: 2-Hydroxytropone, alpha-Tropolone, NSC 89303, Purpurocatechol. Molecular Formula: C7H6O2. Formula Weight: 122.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 10mg/mL, Ethanol: 30mg/mL, Ethanol:PBS (pH 7.2) (1:6): 0.14mg/mL. lambdamax: 227, 319, 352 nm. SMILES: OC1=CC=CC=CC1=O. InChi Code: InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9). InChi Key: MDYOLVRUBBJPFM-UHFFFAOYSA-N. Origin: Synthetic.