Trimethobenzamide (hydrochloride)

Trimethobenzamide is a dopamine D2 receptor antagonist and antiemetic. It prevents emesis induced by the dopamine agonist apomorphine (Cay-16094) in dogs when used at a dose of 20 mg/kg and stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 µg/mL). Trimethobenzamide (20 mg/kg) decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes. Trimethobenzamide (6.7 g/kg per day for 2 weeks) enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury. Formulations containing trimethobenzamide have been used to treat nausea and vomiting.Formal Name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-benzamide, monohydrochloride. CAS Number: 554-92-7. Synonyms: Ro 2-9578. Molecular Formula: C21H28N2O5 . HCl. Formula Weight: 424.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. lambdamax: 214 nm. SMILES: COC1=CC(C(NCC2=CC=C(OCCN(C)C)C=C2)=O)=CC(OC)=C1OC.Cl. InChi Code: InChI=1S/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4,/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24),1H. InChi Key: WIIZEEPFHXAUND-UHFFFAOYSA-N.