Triamcinolone acetonide

Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.Formal Name: 9-fluoro-11beta,21-dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione. CAS Number: 76-25-5. Synonyms: NSC 21916, TrA. Molecular Formula: C24H31FO6. Formula Weight: 434.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 240 nm. SMILES: CC1(C)O[C@]2([H])C[C@@]3([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(CO)=O)O1)=O. InChi Code: InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1. InChi Key: YNDXUCZADRHECN-JNQJZLCISA-N.