trans-hydroxy Glimepiride

Description: trans-Hydroxy Glimepiride is an active metabolite of the sulfonylurea glimepiride, formed primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9. Target: Others. Smiles: CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]2CC[C@H](CO)CC2)C1=O , wU:25.25,wD:28.29,c:2,(-10.49,-16.51,,-8.96,-16.35,,-8.34,-14.94,,-9.11,-13.61,,-10.64,-13.45,,-8.08,-12.46,,-6.67,-13.09,,-5.33,-12.32,,-4,-13.09,,-5.33,-10.78,,-4,-10.01,,-4,-8.47,,-2.67,-7.7,,-2.67,-6.16,,-1.33,-5.39,,,-6.16,,,-7.7,,-1.33,-8.47,,1.33,-5.39,,.56,-4.06,,2.1,-6.72,,2.67,-4.62,,4,-5.39,,4,-6.93,,5.33,-4.62,,6.67,-5.39,,8,-4.62,,9.34,-5.39,,9.34,-6.93,,10.67,-7.7,,10.67,-9.24,,8,-7.7,,6.67,-6.93,,-6.83,-14.62,,-5.68,-15.65,), . References: Langtry, H.D., and Balfour, J.A.Glimepiride. A review of its use in the management of type 2 diabetes mellitusDrugs55(4)563-584(1998)