trans-3'-Hydroxycotinine

trans-3'-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Cay-15314). Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity. This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.Formal Name: 3R-hydroxy-1-methyl-5S-(3-pyridinyl)-2-pyrrolidinone. CAS Number: 34834-67-8. Synonyms: 3HC. Molecular Formula: C10H12N2O2. Formula Weight: 192.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 262 nm. SMILES: O=C1C(O)C[C@@H](C2=CC=CN=C2)N1C. InChi Code: InChI=1S/C10H12N2O2/c1-12-8(5-9(13)10(12)14)7-3-2-4-11-6-7/h2-4,6,8-9,13H,5H2,1H3/t8-,9?/m0/s1. InChi Key: XOKCJXZZNAUIQN-IENPIDJESA-N.