Trametinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9... more
Product information "Trametinib"
Description: Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. Target: Apoptosis, MEK, Autophagy. Smiles: N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5. References: Wabitsch S, et al. Anti-PD-1 in Combination With Trametinib Suppresses Tumor Growth and Improves Survival of Intrahepatic Cholangiocarcinoma in Mice. Cell Mol Gastroenterol Hepatol. 2021,12(3):1166-1178.
| Keywords: | JTP-74057, GSK1120212 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2125 |
Properties
| MW: | 615.39 D |
| Formula: | C26H23FIN5O4 |
Database Information
| CAS : | 871700-17-3| Matching products |
| Protein Atlas Nr. : | Apoptosis, Cell Cycle, DNA Repair |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H317, H361, H372 |
| P Phrases: | P201, P202, P260, P261, P264, P270, P272, P280, P314, P321, P302+P352, P308+P313, P333+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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