TP-040

TP-040 is an O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It is selective for OGA over beta-hexosaminidase (IC50 = >10 µM) and a panel of 277 kinases (IC50s = >1 µM for all). TP-040 increases the levels of O-GlcNAcylated proteins in SH-SY5Y neuroblastoma cells (EC50 = 450 nM).Formal Name: N-[(1-methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine. CAS Number: 2757254-99-0. Synonyms: O-GlcNAcase-IN-1, O-GlcNAcase Inhibitor 1, OGA-IN-1, OGA Inhibitor 1. Molecular Formula: C15H22N6. Formula Weight: 286.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, Chloroform: Sparingly soluble: 1-10 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml. SMILES: CC(CC1)CCN1C2=NC(NCC3=CN(C)C=N3)=NC=C2. InChi Code: InChI=1S/C15H22N6/c1-12-4-7-21(8-5-12)14-3-6-16-15(19-14)17-9-13-10-20(2)11-18-13/h3,6,10-12H,4-5,7-9H2,1-2H3,(H,16,17,19). InChi Key: PWKAYICUBVNJAZ-UHFFFAOYSA-N.