Topotecan (hydrochloride)

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells with (IC50s = 33 and 280 nM, respectively. Formulations containing topotecan have been used in the treatment of small-cell lung cancer.Formal Name: 10-[(dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, monohydrochloride. CAS Number: 119413-54-6. Synonyms: NSC 609669, SKF 104864A. Molecular Formula: C23H23N3O5 . HCl. Formula Weight: 457.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 224, 267, 318, 333, 384 nm. SMILES: O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3CN(C)C)C3=C4)=C4C5)N5C2=O.Cl. InChi Code: InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20,/h5-8,27,30H,4,9-11H2,1-3H3,1H/t23-,/m0./s1. InChi Key: DGHHQBMTXTWTJV-BQAIUKQQSA-N.