Topoisomerase IV inhibitor 1

Description: Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 µM for TOPO IV and 0.43 µM for DNA gyrase. It demonstrates antibacterial efficacy, with minimum inhibitory concentrations (MICs) of 0.972 µM against Staphylococcus aureus Newman and 0.608 µM against Escherichia coli ATCC8739 [1]. Target: Topoisomerase. Smiles: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCN(CC4)CCC(=O)NC5=CC=C(C=C5)S(=O)(=O)NC6=NC7=CC=CC=C7N=C6)F)C(=O)O