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Tolazoline is an alpha1-adrenergic receptor (alpha1-AR, IC50 = 3,200 nM) and alpha2-AR antagonist (Kis = 112, 1,230, 354, and 173 nM for alpha2A, alpha2B-, alpha2C-, and alpha2D-ARs, respectively). Tolazoline inhibits alpha-AR agonist-induced contractions in isolated human corpus cavernosum smooth muscle (IC50 = 0.1 µM). It also lowers vascular resistance in isolated perfused porcine skin flaps (IPPSFs) preconstricted by norepinephrine with an EC50 value of 288 nM. Formulations containing tolazoline have been used in veterinary medicine to reverse the analgesia and sedation induced by xylazine in horses.Formal Name: 4,5-dihydro-2-(phenylmethyl)-1H-imidazole, monohydrochloride. CAS Number: 59-97-2. Molecular Formula: C10H12N2 . HCl. Formula Weight: 196.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C1(CC2=NCCN2)=CC=CC=C1.Cl. InChi Code: InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10,/h1-5H,6-8H2,(H,11,12),1H. InChi Key: RHTNTTODYGNRSP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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