TMS

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids, eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.Formal Name: 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene. CAS Number: 24144-92-1. Synonyms: 2,3',4,5'-Tetramethoxystilbene. Molecular Formula: C18H20O4. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 500 µg/ml, DMSO: 20 mg/ml, Ethanol: 400 µg/ml. lambdamax: 219, 302, 326 nm. SMILES: COC1=CC(/C=C/C2=C(OC)C=C(OC)C=C2)=CC(OC)=C1. InChi Code: InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+. InChi Key: JDBCWSHYEQUBLW-AATRIKPKSA-N.