TLR7/8 Agonist 1 (hydrochloride)

TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8 (EC50s = 50 and 55 nM, respectively, in cell-based assays). It increases the levels of TNF-alpha, IFN-gamma, IL-12p40, and chemokine (C-C motif) ligand 4 (CCL4) in human peripheral blood mononuclear cells (PBMCs) in a biphasic manner. TLR7/8 agonist 1 (25 nmol, s.c.) increases serum levels of IL-12p40 and chemokine (C-X-C motif) ligand 10 (CXCL10), as well as the number of dendritic cells per injection-site proximal lymph node, in mice. It has been conjugated to various fluorophores as TLR7 probes and to polymer particles for the modulation of TLR7/8 agonist 1 adjuvant activity.Formal Name: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine, dihydrochloride. CAS Number: 1620278-72-9. Synonyms: Toll-Like Receptor 7/8 Agonist 1. Molecular Formula: C22H25N5 . 2HCl. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 229, 247, 310, 323 nm. SMILES: NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=C(CN)C=C4.Cl.Cl. InChi Code: InChI=1S/C22H25N5.2ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16,,/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25),2*1H. InChi Key: YKZCFKIAMHQQAW-UHFFFAOYSA-N.