Tipifarnib
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Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86... more
Product information "Tipifarnib"
Tipifarnib is a nonpeptidomimetic, CAAX-competitive inhibitor of farnesyltransferase (IC50 = 0.86 nM). It prevents farnesylation of Ras GTPases and has shown potent efficacy in various in vitro and in vivo tumor models.Formal Name: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone. CAS Number: 192185-72-1. Synonyms: R 115777. Molecular Formula: C27H22Cl2N4O. Formula Weight: 489.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 237, 285, 340 nm. SMILES: ClC1=CC=CC(C(C2=C3C=CC([C@@](C4=CC=C(Cl)C=C4)(N)C5=CN=CN5C)=C2)=CC(N3C)=O)=C1. InChi Code: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1. InChi Key: PLHJCIYEEKOWNM-HHHXNRCGSA-N.
| Keywords: | R 115777, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 11747 |
Properties
| Application: | CAAX-competitive farnesyltransferase inhibitor, Ras GTPase farnesylation inhibitor |
| MW: | 489.4 D |
| Formula: | C27H22Cl2N4O |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 192185-72-1| Matching products |
| KEGG ID : | K05955 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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