Tiopronin-d3

Tiopronin-d3 is intended for use as an internal standard for the quantification of tiopronin (Cay-23720) by GC- or LC-MS. Tiopronin is an antioxidant that has diverse biological activities. It reduces free radical production by murine macrophages and granulocytes in vitro in a dose-dependent manner. Tiopronin induces expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and increases VEGF secretion in human colon carcinoma cells. Rectal administration (500 µl of a 10 mM solution) reduces myeloperoxidase activity and reduces pro-inflammatory cytokine production in the colon in a rat model of colitis. Tiopronin (80-320 mg/kg per day) reduces the incidence of cleft palate in fetuses born to female mice orally exposed to teratogenic methylmercury chloride. Tiopronin (100 mg/kg) reduces heme oxygenase 1 mRNA expression, lipid peroxidation, and transverse aortic constriction in a mouse model of cardiac hypertrophy. Tiopronin (20 mg/kg) is hepatoprotective, increasing activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase and reversing hepatocyte degeneration in a rat model of high-fat diet-induced non-alcoholic steatohepatitis.Formal Name: N-(2-mercapto-1-oxopropyl-3,3,3-d3)-glycine. CAS Number: 1189700-74-0. Synonyms: (±)-Tiopronin-d3. Molecular Formula: C5H6D3NO3S. Formula Weight: 166.2. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble, Water: Soluble. SMILES: OC(CNC(C(S)C([2H])([2H])[2H])=O)=O. InChi Code: InChI=1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)/i1D3. InChi Key: YTGJWQPHMWSCST-FIBGUPNXSA-N.