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Product information "Tin(IV) Protoporphyrin IX Chloride"
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Cay-17161). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. Tin(IV) protoporphyrin IX chloride is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin(IV) protoporphyrin IX chloride prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. Tin(IV) protoporphyrin IX chloride is commonly used as a tool to study the role of HO-1 activity in cells and in animals.Formal Name: (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-stannate(2-), dihydrogen. CAS Number: 14325-05-4. Synonyms: NSC 267099, SnPPIX. Molecular Formula: C34H30Cl2N4O4Sn . 2H. Formula Weight: 750.3. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 405, 541, 579 nm. SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Sn+4]35([Cl-])([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,,,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),2*1H,/q,,,+4/p-4/b25-13-,26-. InChi Key: HDGCWLZQBOZSGG-UHEVNVKKSA-J.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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