Timosaponin AIII
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by... more
Product information "Timosaponin AIII"
Description: Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 µM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 µM, BT474 cells, 6 µM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both. Target: AChE, mTOR. Smiles: CC1C2C(CC3C4CCC5CC(CCC5(C)C4CCC23C)OC2OC(CO)C(O)C(O)C2OC2OC(CO)C(O)C(O)C2O)OC11CCC(C)CO1. References: Wu ZT, et al. Acta Pharmacol Sin. 2014 Sep,35(9):1188-98.
| Keywords: | Filiferin B, Timosaponin A3, AneMarsaponin A3 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3395 |
Properties
| MW: | 740.92 D |
| Formula: | C39H64O13 |
Database Information
| CAS : | 41059-79-4| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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