Tideglusib

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARgamma antagonist GW9662 (Cay-70785). Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3beta (GSK3beta) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer's therapy.Formal Name: 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione. CAS Number: 865854-05-3. Synonyms: NP031112. Molecular Formula: C19H14N2O2S. Formula Weight: 334.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 225, 285 nm. SMILES: O=C(N(CC1=CC=CC=C1)C2=O)SN2C3=C4C(C=CC=C4)=CC=C3. InChi Code: InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2. InChi Key: PMJIHLSCWIDGMD-UHFFFAOYSA-N.