Thioredoxin Reductase 1 Inhibitor 1

Thioredoxin reductase 1 inhibitor 1 (TRi-1) is an irreversible inhibitor of thioredoxin reductase 1 (TrxR1, IC50 = 0.012 µM). It inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 = 4.3 µM). TRi-1 (10 µM) reduces the mitochondrial oxygen consumption rate in HCT116 colorectal cancer cells. It increases the intracellular levels of hydrogen peroxide in FaDu head and neck squamous cell carcinoma (HNSCC) cells in a time- and concentration-dependent manner. TRi-1 decreases the viability of FaDu cells (IC50 = 0.72 µM). In vivo, TRi-1 (10 mg/kg twice per day) decreases tumor growth in a FaDu HNSCC mouse xenograft model. It induces intratumoral apoptosis in a FaDu HNSCC mouse xenograft model when administered at a dose of 5 mg/kg daily. TRi-7 also is toxic to S. mansoni adult worms (LD50 = 10.07 µM).Formal Name: 2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitro-pyridine. CAS Number: 246020-68-8. Synonyms: TRi-1, TxnR1 Inhibitor 1, Txnrd1 Inhibitor 1. Molecular Formula: C12H9ClN2O5S. Formula Weight: 328.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: COC1=CC=C([N+]([O-])=O)C(S(C2=CC=C(Cl)C=C2)(=O)=O)=N1. InChi Code: InChI=1S/C12H9ClN2O5S/c1-20-11-7-6-10(15(16)17)12(14-11)21(18,19)9-4-2-8(13)3-5-9/h2-7H,1H3. InChi Key: PRKWNRUVAZZHPH-UHFFFAOYSA-N.