Thio-TEPA

Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 µM against P388 murine leukemia cells). It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 µM) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro. In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells. It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.Formal Name: 1,1',1''-phosphinothioylidynetris-aziridine. CAS Number: 52-24-4. Synonyms: NCI C01649, NSC 6396, Triethylenethiophosphoramide. Molecular Formula: C6H12N3PS. Formula Weight: 189.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: Soluble. SMILES: S=P(N1CC1)(N2CC2)N3CC3. InChi Code: InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2. InChi Key: FOCVUCIESVLUNU-UHFFFAOYSA-N.