Theophylline-d6

Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline (Cay-23760) by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase (PDE, Ki = 100 µM). It is also an adenosine A1 and A2 receptor antagonist (Ki = 14 µM for both). Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine (EC40 = 117 µM). It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).Formal Name: 3,9-dihydro-1,3-di(methyl-d3)-1H-purine-2,6-dione. CAS Number: 117490-39-8. Synonyms: 1,3-Dimethylxanthine-d6. Molecular Formula: C7H2D6N4O2. Formula Weight: 186.2. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 271 nm. SMILES: O=C1N(C([2H])([2H])[2H])C(C(N=CN2)=C2N1C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)/i1D3,2D3. InChi Key: ZFXYFBGIUFBOJW-WFGJKAKNSA-N.