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Description: TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1beta, IL-6, IL-12, IL-23 and TNF-alpha induced by the EP2-selective agonist butaprost in P388D1 macrophages. Target: Prostaglandin Receptor. Smiles: CCC1=NN=C(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)\C=C\C3=CC=C(F)C=C3)C=C2)S1. References: Ganesh T, Jiang J, Shashidharamurthy R, Dingledine R. Discovery and characterization of carbamothioylacrylamides as EP(2) selective antagonists. ACS Med Chem Lett. 2013 Jul 11,4(7):616-621. PubMed PMID: 23914286, PubMed Central PMCID: PMC3731160.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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