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Description: TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. Target: Prostaglandin Receptor. Smiles: COc1cc(\C=C\C(=O)NCCn2c(C)cc3ccccc23)cc(OC)c1OC. References: Jiang J , Ganesh T , Du Y , et al. Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2[J]. Proceedings of the National Academy of Sciences, 2012, 109(8):3149-3154.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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