TFB-TBOA (hydrate)

TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells. It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 µM. TFB-TBOA (10 µM) inhibits L-glutamate- and L-aspartate-induced currents in X. laevis oocytes. It induces convulsions in mice when administered at a dose of 0.2 µg/animal.Formal Name: (3S)-3-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid, hydrate. Synonyms: CF3-Bza-TBOA. Molecular Formula: C19H17F3N2O6 . XH2O. Formula Weight: 426.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: FC(F)(F)C1=CC=C(C(NC2=CC=CC(CO[C@H](C(O)=O)[C@H](N)C(O)=O)=C2)=O)C=C1.O. InChi Code: InChI=1S/C19H17F3N2O6.H2O/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27,/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29),1H2/t14-,15-,/m0./s1. InChi Key: BGQSOHVMCTUIIO-YYLIZZNMSA-N.