Tetra-O-methylscutellarein

Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-kappaB pathway. It suppressed IkappaB kinase complex alpha/beta (IKKalpha/beta) and Inhibitory-kappa-B-alpha (IkappaBalpha), inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity. Product References: (1) M. Miyazawa, et al., J. Agric. Food Chem. 47, 5239 (1999) , (2) G.L. Maia, et al., Molecules 16, 4828 (2011) , (3) H. Pandith, et al., J. Ethnopharmacol. 147, 434 (2013) Appearance: White to yellow powder. Solubility: Soluble in DMSO (20mg/ml) or chloroform. Identity: Determined by 1H-NMR. InChi Key: URSUMOWUGDXZHU-UHFFFAOYSA-N Smiles: O=C(C=C(C1=CC=C(OC)C=C1)O2)C3=C2C=C(OC)C(OC)=C3OC