Terpendole I

Description: Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT, IC50 = 145 µM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 µg/ml for all) or the fungus C. albicans (MIC = 200 µg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 µM.3. Target: Others. Smiles: [H][C@]12Cc3c([nH]c4ccccc34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H]([C@@H](O)[C@H]4O[C@@]34[C@]1(O)CC2)C(C)(C)O. References: Tomoda, H., Tabata, N., Yang, D.-J., et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J. Antibiot. (Tokyo) 48(8), 793-804 (1995).