Tenapanor (hydrochloride)

Tenapanor is an orally bioavailable inhibitor of sodium-hydrogen exchanger 3 (NHE-3, IC50 = 10 nM for the recombinant rat protein). Tenapanor (10 µM) inhibits intestinal fluid absorption in mouse jejunum, but not distal colon, in a closed intestine loop assay. It also lowers both the sodium and phosphate urinary-to-dietary ratio in a dose-dependent manner in rats. Tenapanor (5 mg/kg) reverses decreases in stool pellet numbers and water content induced by loperamide (Cay-14875) and prevents loperamide-induced constipation in mice. Formulations containing tenapanor have been used in the treatment of irritable bowel syndrome with constipation.Formal Name: 17-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide, dihydrochloride. CAS Number: 1234365-97-9. Synonyms: AZD 1722. Molecular Formula: C50H66Cl4N8O10S2 . 2HCl. Formula Weight: 1218.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: O=S(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C1=CC=CC([C@@]2(CN(C)CC3=C(Cl)C=C(C=C23)Cl)[H])=C1)=O)=O)=O)(C4=CC([C@@]5([H])C6=CC(Cl)=CC(Cl)=C6CN(C5)C)=CC=C4)=O.Cl.Cl. InChi Code: InChI=1S/C50H66Cl4N8O10S2.2ClH/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-48(46)54,,/h5-10,25-30,43-44,59-60H,3-4,11-24,31-34H2,1-2H3,(H2,55,57,63)(H2,56,58,64),2*1H/t43-,44-,,/m0../s1. InChi Key: VFRAXTZDILCRKY-OWRGXFNZSA-N.