This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Tenalisib is an inhibitor of PI3Kdelta and PI3Kgamma (IC50s = 24.5 and 33.2 nM, respectively). It is greater than 300- and 120-fold selective for PI3Kdelta and PI3Kgamma, respectively, over PI3Kalpha and PI3Kbeta. Tenalisib (10 µM) induces cell death in L-540, KM-H2, and L-428 Hodgkin lymphoma cells. It induces cell cycle arrest at the G0/G1 phase in the same cells. In vivo, tenalisib reduces tumor growth and vasculature, induces tumor necrosis, and induces the M1 phenotype in tumor-associated macrophages (TAMs) in an L-540 mouse xenograft model.Formal Name: 3-(3-fluorophenyl)-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4H-1-benzopyran-4-one. CAS Number: 1639417-53-0. Synonyms: RP 6530. Molecular Formula: C23H18FN5O2. Formula Weight: 415.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: O=C1C(C2=CC=CC(F)=C2)=C([C@H](CC)NC3=C4C(N=CN4)=NC=N3)OC5=CC=CC=C51. InChi Code: InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m0/s1. InChi Key: HDXDQPRPFRKGKZ-INIZCTEOSA-N.
Keywords:
RP 6530, 3-(3-fluorophenyl)-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4H-1-benzopyran-4-one
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information