Temsirolimus
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 µM), used in the... more
Product information "Temsirolimus"
Description: Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 µM), used in the treatment of advanced renal cell cancer. Target: Apoptosis, mTOR, Autophagy. Smiles: CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OC(=O)C(C)(CO)CO. References: Shor B, et al. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res. 2008 Apr 15,68(8):2934-43.
| Keywords: | NSC 683864, CCI-779 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2145 |
Properties
| Application: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| MW: | 1030.29 D |
| Formula: | C56H87NO16 |
Database Information
| CAS : | 162635-04-3| Matching products |
| KEGG ID : | K07203 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H360, H410 |
| P Phrases: | P201, P202, P273, P280, P391, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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