Telmisartan-d3

Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Cay-11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Cay-71740, EC50 = 4.5 µM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.Formal Name: 4'-((7'-methyl-1-(methyl-d3)-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. CAS Number: 1189889-44-8. Molecular Formula: C33H27D3N4O2. Formula Weight: 517.6. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble. SMILES: CC1=CC(C2=NC3=C(C=CC=C3)N2C([2H])([2H])[2H])=CC4=C1N=C(CCC)N4CC5=CC=C(C6=CC=CC=C6C(O)=O)C=C5. InChi Code: InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)/i3D3. InChi Key: RMMXLENWKUUMAY-HPRDVNIFSA-N.