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Description: Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.52 µM for porcine, canine, and human H+/K+-ATPases in vitro). Target: ATPase, Proton pump. Smiles: CN(C)C(=O)c1cc(O[C@H]2CCOc3cc(F)cc(F)c23)c2[nH]c(C)nc2c1. References: Takahashi N, et al. Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility. J Pharmacol Exp Ther. 2018 Feb,364(2):275-286.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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