Tegoprazan

Tegoprazan is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles (IC50 = 0.53 µM). It completely inhibits basal gastric acid secretion in pylorus-ligated rats when administered at a dose of 10 mg/kg and reduces esophageal mucosal tissue levels of myeloperoxidase (MPO), a marker of tissue damage, in a rat model of reflux esophagitis (ED50 = 5.9 mg/kg). Tegoprazan reduces ulcer area in rat models of gastric ulcers induced by naproxen, water-immersion restraint stress (WIRS), or ethanol (ED50s = 0.1, 0.1, and 1.4 mg/kg, respectively).Formal Name: 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide. CAS Number: 942195-55-3. Synonyms: CJ-12420. Molecular Formula: C20H19F2N3O3. Formula Weight: 387.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 220 nm. SMILES: CN(C)C(C1=CC(O[C@@H]2C3=C(F)C=C(F)C=C3OCC2)=C4C(N=C(N4)C)=C1)=O. InChi Code: InChI=1S/C20H19F2N3O3/c1-10-23-14-6-11(20(26)25(2)3)7-17(19(14)24-10)28-15-4-5-27-16-9-12(21)8-13(22)18(15)16/h6-9,15H,4-5H2,1-3H3,(H,23,24)/t15-/m0/s1. InChi Key: CLIQCDHNPDMGSL-HNNXBMFYSA-N.