Tebufenozide

Tebufenozide is an insecticide that acts as a non-steroidal agonist of the insect ecdysone receptor (EcR, IC50 = 0.85 nM in a cell-free preparation of C. suppressalis integument). It induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva). It also inhibits P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), activity in LLC-PK1 porcine kidney epithelial cells expressing human P-gp (IC50 = 21.5 µM). Tebufenozide has low toxicity in mammals, birds, and most aquatic species, but it dose-dependently decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 µg/ml. Formulations containing tebufenozide have been used as insecticides, miticides, sex attractants, and/or feeding stimulants in agricultural, aquatic, and residential areas.Formal Name: 3,5-dimethyl-1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide, benzoic acid. CAS Number: 112410-23-8. Synonyms: RH-5992. Molecular Formula: C22H28N2O2. Formula Weight: 352.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CCC1=CC=C(C(NN(C(C)(C)C)C(C2=CC(C)=CC(C)=C2)=O)=O)C=C1. InChi Code: InChI=1S/C22H28N2O2/c1-7-17-8-10-18(11-9-17)20(25)23-24(22(4,5)6)21(26)19-13-15(2)12-16(3)14-19/h8-14H,7H2,1-6H3,(H,23,25). InChi Key: QYPNKSZPJQQLRK-UHFFFAOYSA-N.