TCS ERK 11e

TCS ERK 11e is an orally bioavailable inhibitor of extracellular signal-related kinase 2 (ERK2, Ki i values of 395, 540, and 852 nM, respectively. TCS ERK 11e has been shown to block the proliferation of HT29 cells with an IC50 value of 48 nM.Formal Name: 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide. CAS Number: 896720-20-0. Synonyms: TCS Extracellular Signal-Related Kinase 11e, VX-11e. Molecular Formula: C24H20Cl2FN5O2. Formula Weight: 500.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMSO: 25 mg/mL, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/mL, Ethanol: 1 mg/mL. lambdamax: 266, 329 nm. SMILES: FC1=CC=C(NC2=NC=C(C)C(C3=CNC(C(N[C@H](CO)C4=CC(Cl)=CC=C4)=O)=C3)=N2)C(Cl)=C1. InChi Code: InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1. InChi Key: WUTVMXLIGHTZJC-OAQYLSRUSA-N.