TASP0415914

TASP0415914 is a PI3Kgamma inhibitor (IC50 = 29 nM). It is selective for PI3Kgamma over Akt (IC50 = 294 nM). In vivo, TASP0415914 (30 and 100 mg/kg) reduces ankle redness and swelling in a mouse model of collagen-induced arthritis.Formal Name: N-[5-[3-(3-hydroxy-1-piperidinyl)-1,2,4-oxadiazol-5-yl]-4-methyl-2-thiazolyl]-acetamide. CAS Number: 1292300-75-4. Molecular Formula: C13H17N5O3S. Formula Weight: 323.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: CC(N=C(NC(C)=O)S1)=C1C2=NC(N3CCCC(O)C3)=NO2. InChi Code: InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19). InChi Key: WFQFHKQIDOCQTL-UHFFFAOYSA-N.