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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| TGM-T41145-5mg | 5 mg |
7 - 10 business days* |
777.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor... more
Product information "TASP 0277308"
Description: TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia. Target: Others. Smiles: O(C=1N(CC)C([C@H](NS(=O)(=O)C2=CC(Cl)=C(Cl)C=C2)C)=NN1)C3=CC(=CC=C3)N4CCN(C)CC4. References: Fujii et al (2012) Amelioration of collagen-induced arthritis by a novel S1P 1 antagonist with immunomodulatory activities. J.Immunol. 188 PMID: 22131329
| Supplier: | TargetMol |
| Supplier-Nr: | T41145 |
Properties
| Application: | S1P1 antagonist |
| MW: | 539.48 D |
| Formula: | C23H28Cl2N6O3S |
Database Information
| CAS : | 945725-50-8| Matching products |
| KEGG ID : | K04288 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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