Tasosartan

Tasosartan is an angiotensin II type 2 (AT2) receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes). It also binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells). Tasosartan (3 mg/kg, intraduodenally) reduces the AT2-induced pressor response in rats. It also decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction when administered intragastrically or intravenously at doses of 1 and 3 mg/kg.Formal Name: 5,8-dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-pyrido[2,3-d]pyrimidin-7(6H)-one. CAS Number: 145733-36-4. Synonyms: WAY-ANA-756. Molecular Formula: C23H21N7O. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 14 mg/ml, Ethanol: 2 mg/ml. lambdamax: 251 nm. SMILES: CC1=NC(C)=C(CCC(N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)=O)C2=N1. InChi Code: InChI=1S/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29). InChi Key: ADXGNEYLLLSOAR-UHFFFAOYSA-N.