Tanshinone IIA

Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-alpha, IL-1beta, IL-6, NO, INFgamma, and expression of iNOS, and IL-12. It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways. It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.Formal Name: 6,7,8,9-tetrahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione. CAS Number: 568-72-9. Synonyms: NSC 686518, NSC 686519, TSA. Molecular Formula: C19H18O3. Formula Weight: 294.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 0.3 mg/ml. lambdamax: 223, 269, 454 nm. SMILES: CC1=COC(C2=C3C4=C(C=C2)C(C)(C)CCC4)=C1C(C3=O)=O. InChi Code: InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3. InChi Key: HYXITZLLTYIPOF-UHFFFAOYSA-N.