Tamoxifen (citrate)

Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It decreases tumor proliferation, weight, and volume in an MCF-7 mouse xenograft model when administered at a dose of 100 µg/animal per day. Tamoxifen (0.8 mg/kg every two weeks) also reduces proteinuria and increases survival in an NZBWF1 mouse model of systemic lupus erythematosus (SLE). It can be used as a regulator for Cre-recombinase inducible gene expression in vivo. Formulations containing tamoxifen have been used in the treatment of estrogen receptor-positive breast cancer.Formal Name: 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate. CAS Number: 54965-24-1. Synonyms: ICI 46474, TMX. Molecular Formula: C26H29NO . C6H8O7. Formula Weight: 563.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 237, 276 nm. SMILES: CN(C)CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CC)C=C1.OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3,7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-,. InChi Key: FQZYTYWMLGAPFJ-OQKDUQJOSA-N.