Tamoxifen

Tamoxifen
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CDX-T0200-G001 1 g - -

3 - 9 business days*

77.00€
CDX-T0200-G005 5 g - -

3 - 9 business days*

307.00€
 
Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective... more
Product information "Tamoxifen"
Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen) and 4-hydroxy-TMX (afimoxifene). N,N-Didesmethyl-4-hydroxytamoxifen (norendoxifen), another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C (PKC) inhibitor and anti-angiogenetic factor.
Keywords: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
Supplier: Chemodex
Supplier-Nr: T0200

Properties

Application: Selective estrogen receptor modulator
MW: 371,51 D
Formula: C26H29NO
Format: Solid

Database Information

CAS : 10540-29-1| Matching products
KEGG ID : K08550 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H350, H360, H362
P Phrases: P201, P263, P308+P313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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