T-705

T-705 is an antiviral agent that inhibits influenza A, B, and C (IC50s = 0.013-0.48 µg/ml) without inducing cytotoxicity up to 1,000 µg/ml. It inhibits a neuraminidase-resistant influenza strain (GS4071-resistant, IC50 = 0.095 µg/ml) and RNA viruses (IC50s = 4.8-41 µg/ml) but not DNA viruses at concentrations greater than 100 µg/ml. It is active against a variety of viruses, including bunyavirus, arenavirus, and West Nile virus in vitro and in vivo in mice. T-705 undergoes phosphoribosylation to form T-705-RTP, which inhibits RNA-dependent RNA polymerase (RdRp) in RNA viruses. In mice infected with influenza virus, T-705 (200 mg/kg once daily) decreases the rate of mortality and reduces the lung virus yield in a dose-dependent manner at doses ranging from 50-200 mg/kg per day.Formal Name: 6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide. CAS Number: 259793-96-9. Synonyms: Favilavir, Favipiravir. Molecular Formula: C5H4FN3O2. Formula Weight: 157.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 222, 323 nm. SMILES: FC1=CNC(C(C(N)=O)=N1)=O. InChi Code: InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11). InChi Key: ZCGNOVWYSGBHAU-UHFFFAOYSA-N.