T-5342126

Description: T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM) and decreases LPS-induced IL-8, TNF-alpha, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice. Target: Others. Smiles: C(N1C(C)=C(CN(CC(COC2=CC=C(OCC)C=C2)O)C)C(C)=N1)C3=C(Cl)C=CC=C3. References: Chavez, S.A., Martinko, A.J., Lau, C., et al.Development of beta-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antisepticsJ. Med. Chem.54(13)4659-4669(2011)