SYP-5

SYP-5 is an inhibitor of hypoxia-inducible factor-1 (HIF-1). It inhibits HIF-1 activity in a reporter assay when used at concentrations ranging from 0.1 to 100 µM. SYP-5 (2, 10, and 50 µM) reduces hypoxia- or VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It inhibits the migration and invasion of Hep3B hepatocellular carcinoma and BCaP-37 breast cancer cells in a concentration-dependent manner.Formal Name: (2E)-1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-2-propen-1-one. CAS Number: 1384268-04-5. Molecular Formula: C18H16O3S. Formula Weight: 312.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 233, 283, 369 nm. SMILES: OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=CS3)=O. InChi Code: InChI=1S/C18H16O3S/c1-18(2)10-9-14-16(21-18)8-6-13(17(14)20)15(19)7-5-12-4-3-11-22-12/h3-11,20H,1-2H3/b7-5+. InChi Key: OMVURDVBYIJCOI-FNORWQNLSA-N.