Syk Inhibitor II (hydrochloride)

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCepsilon, PKCbetaII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Syk inhibitor II has been shown to prevent FcepsilonRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).Formal Name: 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide, dihydrochloride. CAS Number: 227449-73-2. Synonyms: Spleen Tyrosine Kinase Inhibitor II. Molecular Formula: C14H15F3N6O . 2HCl. Formula Weight: 413.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.3 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 255, 285 nm. SMILES: NCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1.Cl.Cl. InChi Code: InChI=1S/C14H15F3N6O.2ClH/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18,,/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23),2*1H. InChi Key: OWOVYLSSMDVDIW-UHFFFAOYSA-N.