Swertiamarin

Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties. It scavenges ABTS (Cay-27317) radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 µM, respectively). Swertiamarin (50 µg/ml) inhibits nitric oxide (NO) production in IL-1beta-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaw. Swertiamarin (25 µg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells. It decreases liver lipid accumulation, ballooning degeneration, and TNF-alpha and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day. Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104).Formal Name: (4aR,5R,6S)-5-ethenyl-6-(beta-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one. CAS Number: 17388-39-5. Molecular Formula: C16H22O10. Formula Weight: 374.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, Ethanol: 3mg/mL, PBS (pH 7.2): 10mg/mL. lambdamax: 238 nm. SMILES: O=C1OCC[C@]2(O)C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2C=C. InChi Code: InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2/t7-,9+,10+,11-,12+,14-,15-,16+/m0/s1. InChi Key: HEYZWPRKKUGDCR-QBXMEVCASA-N. Origin: Plant/Swertia chirayita.