SW203668 (trifluoroacetate salt)

SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.Formal Name: 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide, trifluoroacetate salt. CAS Number: 2117405-48-6. Molecular Formula: C22H19N3O2S . CF3COOH. Formula Weight: 503.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL. lambdamax: 316 nm. SMILES: COC1=CC=C2C(SC(NC(C3=CC=C(C(N)C4=CC=CC=C4)C=C3)=O)=N2)=C1.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C22H19N3O2S.C2HF3O2/c1-27-17-11-12-18-19(13-17)28-22(24-18)25-21(26)16-9-7-15(8-10-16)20(23)14-5-3-2-4-6-14,3-2(4,5)1(6)7/h2-13,20H,23H2,1H3,(H,24,25,26),(H,6,7). InChi Key: SIUPHFAIFLEFIT-UHFFFAOYSA-N.