SW155246

SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1, IC50 = 1.2 µM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 µM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 µM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 µM.Formal Name: 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide. CAS Number: 420092-79-1. Molecular Formula: C16H11ClN2O5S. Formula Weight: 378.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.16 mg/ml. lambdamax: 212, 304 nm. SMILES: ClC1=CC=C(S(NC2=CC=C(O)C3=C2C=CC=C3)(=O)=O)C=C1[N+]([O-])=O. InChi Code: InChI=1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H. InChi Key: JDYDEJYIVZNWQU-UHFFFAOYSA-N.