Suramin (sodium salt)

Suramin is a polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities. It is negatively charged at physiological pH and therefore binds to various intracellular targets including, but not limited to, ryanodine receptor 1 (IC50 = 4.9 µM), G protein-coupled receptors, P2 purinergic receptors, PDGF, PKC, transferrin, DNA and RNA polymerases, sirtuins, and various cytokines. It reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 µg/ml). In vivo, suramin induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis. It also neutralizes the myotoxic effect of basic phospholipase A2 (PLA2) homolog MjTX-I, a Lys49-PLA2 protein from snake venom, in mouse phrenic-diaphragm preparations. Suramin (60 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of malignant mesothelioma. Formulations containing suramin have been used in the treatment of African sleeping sickness.Formal Name: 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt. CAS Number: 129-46-4. Synonyms: BAY 205, Germanin, NF 060. Molecular Formula: C51H34N6O23S6 . 6Na. Formula Weight: 1429.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: >10 mg/ml. SMILES: O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73). InChi Key: VAPNKLKDKUDFHK-UHFFFAOYSA-H.