Sulthiame

Sulthiame is a pan-inhibitor of carbonic anhydrases (CA, Kis = 6-1,540 nM for CAI, -II, and IV-XIV) and an anticonvulsant. It is selective for these CAs over CAIII (Ki = 630 µM). Sulthiame (10 µg/ml) also inhibits voltage-gated sodium currents in isolated guinea pig hippocampal CA1 neurons. It reduces epileptiform activity induced by 4-aminopyridine (Cay-18511) in guinea pig hippocampal slices when used at a concentration of 2.5 mM. Sulthiame (100-300 mg/kg, i.p.) induces neuronal cell death in neonatal rats. It decreases forelimb clonus duration in a rat model of partial epilepsy induced by amygdaloid kindling when administered at doses ranging from 25 to 200 mg/kg. Formulations containing sulthiame have been used in the treatment of epilepsy.Formal Name: 4-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide. CAS Number: 61-56-3. Synonyms: Sultiame. Molecular Formula: C10H14N2O4S2. Formula Weight: 290.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly, Methanol: slightly. SMILES: O=S(N)(C1=CC=C(N2CCCCS2(=O)=O)C=C1)=O. InChi Code: InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16). InChi Key: HMHVCUVYZFYAJI-UHFFFAOYSA-N.