Sulfamethazine

Sulfamethazine is a sulfonamide antibiotic. It inhibits dihydropteroate synthase (DHPS, IC50 = 5.7 µM for the T. gondii enzyme). Sulfamethazine is active against A. pleuropneumoniae (MIC = 32 µg/ml) and enhances the antibacterial activity of trimethoprim (Cay-16473) against E. coli. It has been detected in environmental water samples. Formulations containing sulfamethazine have been used in the treatment of bacterial infections in livestock.Formal Name: 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamide. CAS Number: 57-68-1. Synonyms: NSC 67457, NSC 683529, Sulfadimethyldiazine, Sulfadimidine. Molecular Formula: C12H14N4O2S. Formula Weight: 278.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 211, 269 nm. SMILES: NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1. InChi Code: InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16). InChi Key: ASWVTGNCAZCNNR-UHFFFAOYSA-N.